Atm ELISA Kit for Mouse(Mus musculus) | EIAab.comAtm ELISA Kit for Mouse(Mus musculus)

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Atm (Gene name),

Serine-protein kinase ATM (Protein name ), ATM_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Atm;

Protein name:

Serine-protein kinase ATM;

Alternative:

Ataxia telangiectasia mutated homolog(A-T mutated homolog);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds DNA ends, p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. Interacts with EEF1E1; the interaction, induced on DNA damage, upregulates TP53. Interacts with DCLRE1C, MYST1, KAT5, OBFC2B, ATMIN and CEP164 (By similarity). Interacts with AP2B1 AND AP3B2; the interaction occurs in cytoplasmic vesicles. Interacts with TELO2 AND TTI1. Interacts with DDX1.

Function:

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation.

Subcellular Location:

Nucleus Cytoplasmic vesicle Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.

Protein Attributes:

Sequence length:

3066

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DPKNLSRLFP | GWKAWV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.5088

KEGG:

mmu:11920

Pfam:

PF02259

String:

Q62388

Uniprot:

Q62388

FOR

ELISA Kit for Mouse Serine-protein kinase ATM

Cat.:

E1361p

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Serine-protein kinase ATM

Cat.:

E1361h

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse Serine-protein kinase ATM

Cat.:

E1361m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Serine-protein kinase ATM

Cat.:

U1361m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Serine-protein kinase ATM

Cat.:

U1361h

Price:

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Mouse Serine-protein kinase ATM

Cat.:

U1361p

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Serine-protein kinase ATM

Cat.:

P1361Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Serine-protein kinase ATM

Cat.:

P1361Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Serine-protein kinase ATM

Protein for Mouse Serine-protein kinase ATM

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene."
Pecker I. , Avraham K.B. , Gilbert D.J. , Savitsky K. , Rotman G. , Harnik R. , Fukao T. , Schroeck E. , Hirotsume S. , Tagle D.A. , Collins F.S. , Wynshaw-Boris A. , Ried T. , Copeland N.G. , Jenkins N.A. , Shiloh Y. , Ziv Y.
Genomics35:39-45(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"Analysis of the ATM protein in wild-type and ataxia telangiectasia cells."
Lakin N.D. , Weber P. , Stankovic T. , Rottinghaus S.T. , Taylor A.M.R. , Jackson S.P.
Oncogene13:2707-2716(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
4.

"Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia."
Soares H.D. , Morgan J.I. , McKinnon P.J.
Neuroscience86:1045-1054(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
strain: B6C3-F1.
5.

"ATM binds to beta-adaptin in cytoplasmic vesicles."
Lim D.-S. , Kirsch D.G. , Canman C.E. , Ahn J.-H. , Ziv Y. , Newman L.S. , Darnell R.B. , Shiloh Y. , Kastan M.B.
Proc. Natl. Acad. Sci. U.S.A.95:10146-10151(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2B1 AND AP3B2
6.

"ATM phosphorylates histone H2AX in response to DNA double-strand breaks."
Burma S. , Chen B.P. , Murphy M. , Kurimasa A. , Chen D.J.
J. Biol. Chem.276:42462-42467(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF H2AFX
7.

"Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo."
Daniel J.A. , Pellegrini M. , Lee J.H. , Paull T.T. , Feigenbaum L. , Nussenzweig A.
J. Cell Biol.183:777-783(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-367; SER-1899 AND SER-1987;FUNCTION;MUTAGENESIS OF SER-367; SER-1899 AND SER-1987
8.

"RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci."
Hewitt S.L. , Yin B. , Ji Y. , Chaumeil J. , Marszalek K. , Tenthorey J. , Salvagiotto G. , Steinel N. , Ramsey L.B. , Ghysdael J. , Farrar M.A. , Sleckman B.P. , Schatz D.G. , Busslinger M. , Bassing C.H. , Skok J.A.
Nat. Immunol.10:655-664(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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